Thalidomide-O-amido-PEG3-C2-NH2(Synonyms: Cereblon Ligand-Linker Conjugates 3 ; E3 Ligase Ligand-Linker Conjugates 14)

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Thalidomide-O-amido-PEG3-C2-NH2 (Synonyms: Cereblon Ligand-Linker Conjugates 3 ; E3 Ligase Ligand-Linker Conjugates 14)

Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) 是一种合成的 E3 连接酶配体-linker 偶联物,包含基于 Thalidomide 的 cereblon 配体和 3 个单元的 PEG linker。

Thalidomide-O-amido-PEG3-C2-NH2(Synonyms: Cereblon Ligand-Linker Conjugates 3 ;  E3 Ligase Ligand-Linker Conjugates 14)

Thalidomide-O-amido-PEG3-C2-NH2 Chemical Structure

CAS No. : 1957236-20-2

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Thalidomide-O-amido-PEG3-C2-NH2 的其他形式现货产品:

Thalidomide-O-amido-PEG3-C2-NH2 TFA Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride

生物活性

Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

IC50 & Target[1]

Cereblon

 

体外研究
(In Vitro)

Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) is composed of Degron (E3 ubiquitin ligase) and a linker, and they are used in PROTAC technology. Thalidomide-O-amido-PEG3-C2-NH2 binds to the targeting ligand to induce the target protein (including BRD4, BRD2, and BRD3) degradation[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

506.51

Formula

C23H30N4O9

CAS 号

1957236-20-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017007612 A1

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