CDK8-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CDK8-IN-1 

CDK8-IN-1 是一个有效的、CDK8 的选择性抑制剂，其 IC50 值为 3 nM。

CDK8-IN-1

CDK8-IN-1 Chemical Structure

CAS No. : 1629633-48-2

规格 价格 是否有货
5 mg ￥3500 询问价格 & 货期
10 mg ￥5500 询问价格 & 货期
25 mg ￥9900 询问价格 & 货期
50 mg ￥16500 询问价格 & 货期
100 mg ￥22500 询问价格 & 货期

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生物活性

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.

IC50 & Target[1]

CDK8

3 nM (IC50)

体内研究
(In Vivo)

CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

255.20

Formula

C11H8F3N3O
CAS 号

1629633-48-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492.
Animal Administration
[1]

Mice[1]
CDK8-IN-1 is administrated to mice with 5 mg/kg, 25mg/mg by IV and PO respectively[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492.

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