PROTAC KRAS G12C degrader-1

发表于由

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PROTAC KRAS G12C degrader-1 

PROTAC KRAS G12C degrader-1 是一种基于 Cereblon 的 KRASG12C 降解剂，对 CRBN 的 IC50 为 414 nM。PROTAC KRAS G12C degrader-1 诱导 CRBN/KRASG12C 二聚化并降解报告细胞中的 GFP-KRASG12C。

PROTAC KRAS G12C degrader-1

PROTAC KRAS G12C degrader-1 Chemical Structure

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5 mg ￥12800 询问价格 & 货期
10 mg ￥20500 询问价格 & 货期

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生物活性

PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C degrader, with an IC50 of 414 nM for CRBN. PROTAC KRAS G12C degrader-1 induces CRBN/ KRASG12C dimerization and degrades GFP- KRASG12C in reporter cells[1].

体外研究
(In Vitro)

PROTAC KRAS G12C degrader-1 (Compound 12) engages CRBN in cells, bound KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in reporter cells in a CRBN-dependent manner[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

917.47

Formula

C50H54ClFN8O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zeng M, et, al. Exploring Targeted Degradation Strategy for Oncogenic KRAS G12C. Cell Chem Biol. 2020 Jan 16;27(1):19-31.e6.

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