Neridronate(Synonyms: 奈立膦酸)

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Neridronate (Synonyms: 奈立膦酸) 纯度: ≥98.0%

Neridronate 是一种氨基二膦酸盐，有潜力用于成骨不全症 (OI) 和佩吉特骨病 (PDB)。Neridronate 对其他骨骼疾病也有效，如骨质疏松症，骨痛退化症，恶性高钙血症和骨转移病变。

Neridronate(Synonyms: 奈立膦酸)

Neridronate Chemical Structure

CAS No. : 79778-41-9

规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥2927 In-stock
1 mg ￥960 In-stock
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

Neridronate 相关产品

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生物活性

Neridronate is an aminobisphosphonate, licensed in Italy for the treatment of osteogenesis imperfecta (OI) and Paget’s disease of bone (PDB). Neridronate is effective also in other skeletal diseases such as osteoporosis, algodystrophy, hypercalcemia of malignancy, and bone metastases[1][2].

Clinical Trial

分子量

277.15

Formula

C6H17NO7P2
CAS 号

79778-41-9
中文名称

奈立膦酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : 5 mg/mL (18.04 mM; ultrasonic and warming and adjust pH to 8 with NaOH and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.6082 mL 18.0408 mL 36.0815 mL
5 mM 0.7216 mL 3.6082 mL 7.2163 mL
10 mM 0.3608 mL 1.8041 mL 3.6082 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Gatti D, et al. Clinical development of neridronate: potential for new applications. Ther Clin Risk Manag. 2013;9:139-47.

    [2]. Guiducci L, et al. Monthly Intramuscular Neridronate for the Treatment of Postmenopausal Osteoporosis: Results of a 6-Year Prospective Italian Study. Int J Endocrinol. 2019 Feb 6;2019:9802827.

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