DC0-NH2

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DC0-NH2  纯度: 95.21%

DC0-NH2 是 ADC 的效应部分，是 DC1 的类似物，具有更高的稳定性。 DC0-NH2 的细胞毒性比常用的抗癌药物 (如，阿霉素) 高约 1000 倍。DC0-NH2 可以结合到较小的 DNA 凹槽上，随后通过其丙炔吲哚 (CBI) 部分将腺嘌呤残基烷基化。

DC0-NH2

DC0-NH2 Chemical Structure

CAS No. : 615538-51-7

规格 价格 是否有货 数量
1 mg ￥5500 In-stock
5 mg ￥9800 In-stock
10 mg ￥15000 In-stock
50 mg   询价  
100 mg   询价  

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DC0-NH2 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Toxins for Antibody-Drug Conjugate Research Library

生物活性

DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer drugs (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component[1].

IC50 & Target[1]

Duocarmycins

 

体外研究
(In Vitro)

DC0-NH2(0-3 nM;72小时),在乳腺癌细胞系的活力测定实验中，对Ramos，Namalwa和HL60/s细胞具有很高的抗增殖效力，抑制 Namalwa 和 HL60/s 细胞增殖的 IC50值分别为 7 pM 和 5 pM，对 COLO205 细胞的抑制范围在 100 pM 之内[1]。

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Ramos, Namalwa, HL60/s, and COLO 205 Cancer Cells
Concentration: 0-3 nM
Incubation Time: 72 hours
Result: Inhibited Namalwa and HL60/s cells with IC50s of 7 and 30 pM, respectively.

分子量

550.01

Formula

C31H24ClN5O3
CAS 号

615538-51-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献

  • [1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer.J Med Chem. 2012 Jan 26;55(2):766-82.

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