上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
MB710 纯度: 98.09%
MB710 是一种氨基苯并噻唑衍生物,是致癌 p53 突变体 Y220C 的稳定剂。MB710 与 Y220C 紧密结合并稳定 p53-Y220C,Kd 值为 4 μM。 MB710 在 p53-Y220C 细胞系中显示抗癌活性。
MB710 Chemical Structure
CAS No. : 2230044-57-0
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥6000 | In-stock | |
10 mg | ¥10500 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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生物活性 |
MB710, an aminobenzothiazole derivative, is a stabilizer of oncogenic p53 mutation Y220C. MB710 binds tightly to the Y220C pocket and stabilizes p53-Y220C, with a Kd of 4.1 μM. MB710 shows anticancer activity in p53-Y220C cell lines[1]. |
IC50 & Target |
Kd: 4 μM (p53-Y220C) |
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体外研究 (In Vitro) |
MB710 (0-200 μM; 72 hours) shows relatively low toxicity against all cell lines tested at concentrations up to 60 μM, while showing initial selective viability reduction at higher concentrations[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
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分子量 |
457.29 |
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Formula |
C16H16IN3O3S |
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CAS 号 |
2230044-57-0 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 25 mg/mL (54.67 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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