Tpl2 Kinase Inhibitor 1

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Tpl2 Kinase Inhibitor 1  纯度: 99.08%

Tpl2 Kinase Inhibitor 1 (Compound 1) 是一种有效的选择性 Tpl2 (COT 激酶，MAP3K8) 抑制剂，可用于炎症反应和某些癌症的研究。

Tpl2 Kinase Inhibitor 1

Tpl2 Kinase Inhibitor 1 Chemical Structure

CAS No. : 871307-18-5

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5 mg ￥5150 In-stock
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Tpl2 Kinase Inhibitor 1 相关产品

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生物活性

Tpl2 Kinase Inhibitor 1 (Compound 1) is a potent and selective Tpl2 (COT kinase, MAP3K8) inhibitor, plays an important role in the regulation of the inflammatory response and the progression of some cancers[1].

IC50 & Target

MAP3K8

 

体外研究
(In Vitro)

Cancer Osaka thyroid (COT) kinase (Tpl2) is an important regulator of pro-inflammatory cytokines in macrophages[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

404.83

Formula

C21H14ClFN6
CAS 号

871307-18-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Glatthar R, et al. Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. J Med Chem. 2016 Aug 25;59(16):7544-60.

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