Leptosphaerodione

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Leptosphaerodione 

Leptosphaerodione，可从 Remotididymella sp. 中分离得到，是一种有效的泛素-蛋白酶体系统 (UPS) 抑制剂。Leptosphaerodione 在 HeLa 细胞中具有细胞毒性，IC50 为 3.2 μM。抗肿瘤剂。

Leptosphaerodione

Leptosphaerodione Chemical Structure

CAS No. : 138039-33-5

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生物活性

Leptosphaerodione, isolated from Remotididymella sp. Fungus, is a potent ubiquitin-proteasome system (UPS) inhibitor. Leptosphaerodione exhibits cytotoxicity in HeLa cells with IC50 value of 3.2 μM. Anti-tumor agent[1].

分子量

354.40

Formula

C21H22O5
CAS 号

138039-33-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Soichiro Nishimura, et al. Cell-based screening of extracts of natural sources to search for inhibitors of the ubiquitin-proteasome system and identification of proteasome inhibitors from the fungus Remotididymella sp. Bioorg Med Chem Lett. 2022 Ma

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