CK2 inhibitor 3

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CK2 inhibitor 3 

CK2 inhibitor 3 是一种有效的 CK2 抑制剂，IC50 为 280 nM。CK2 inhibitor 3 可抑制细胞内的 CK2，显著影响肿瘤细胞的活力，并对一组 320 激酶显示出显著的选择性。

CK2 inhibitor 3

CK2 inhibitor 3 Chemical Structure

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生物活性

CK2 inhibitor 3 is a potent CK2 inhibitor with IC50 value of 280 nM. CK2 inhibitor 3 inhibits endocellular CK2, significantly affects viability of tumour cells and shows remarkable selectivity on a panel of 320 kinases[1].

IC50 & Target[1]

CK2

280 nM (IC50)

体外研究
(In Vitro)

CK2 inhibitor 3 (compound 4) (0-50 μM; 24 hours) significantly reduces cell viability in a dose-dependent manner, and DC50 value is 12.80 μM[1].
CK2 inhibitor 3 (5 μM and 20 μM; 16 hours) decreases the CK2-dependent phospho-site Akt Ser129 level[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line: Jurkat cells[1]
Concentration: 0 μM, 10 μM, 20 μM, 30 μM, 40 μM and 50 μM
Incubation Time: 24 hours
Result: Significantly reduced cell viability in a dose-dependent manner, and DC50 value was 12.80 μM.

Western Blot Analysis

Cell Line: Jurkat cells[1]
Concentration: 5 μM and 20 μM
Incubation Time: 16 hours
Result: Decreased the CK2-dependent phospho-site Akt Ser129 level.

分子量

381.20

Formula

C13H9BrN4O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Dalle Vedove A, Zonta F, Zanforlin E, et al. A novel class of selective CK2 inhibitors targeting its open hinge conformation. Eur J Med Chem. 2020;195:112267.

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