Antitumor agent-53

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Antitumor agent-53 

Antitumor agent-53 是一种有效的抗癌剂。Antitumor agent-53 诱导细胞周期停滞在 G2/M 期。Antitumor agent-53 抑制 PI3K/AKT 信号通路并诱导 HGC-27 细胞凋亡 (apoptosis)。Antitumor agent-53 具有研究胃肠道肿瘤的潜力。

Antitumor agent-53

Antitumor agent-53 Chemical Structure

CAS No. : 2757145-67-6

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生物活性

Antitumor agent-53 is a potent antitumor agent. Antitumor agent-53 induces cell cycle arrest at the G2/M phase. Antitumor agent-53 inhibits the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells. Antitumor agent-53 has the potential for the research of gastrointestinal tumors[1].

体外研究
(In Vitro)

Antitumor agent-53 (compound 6f) (0, 0.22, 0.67, 2, 6, 18 µM; 72 h) shows anti-proliferation activity with IC50s of 3.10, 0.37, 4.01, >18, 7.87, 9.11 µM for HGC-27, HT-29, HepG-2, A549, MCF7, GES-1 cells[1].
Antitumor agent-53 (0.15, 0.3, 0.6 µM) shows anti-proliferative activity in HGC-27 and HT-29 cells with a dose-dependent manner[1].
Antitumor agent-53 (100, 200 µM) shows a certain inhibitory activity against Topo I at 200 μM[1].
Antitumor agent-53 (0.1, 0.3, 0.9 μM; 24 h) induces cell cycle arrest at the G2/M phase in HGC-27, HT-29 cells[1].
Antitumor agent-53 (0.1, 0.3, 0.9, 2.7 μM; 24 h) induces the apoptosis of HGC-27 and HT-29 cells in a concentration-dependent manner[1].
Antitumor agent-53 (0.15, 0.3, 0.6 μM; 24 h) inhibits the migration and invasion of HGC-27 cells in a concentration-dependent manner[1].
Antitumor agent-53 (0.1, 0.3, 0.9 μM; 24 h) suppresses the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: HGC-27, HT-29, HepG-2, A549, MCF7, GES-1 cells
Concentration: 0, 0.22, 0.67, 2, 6, 18 µM
Incubation Time: 72 h
Result: Showed anti-proliferation activity with IC50s of 3.10, 0.37, 4.01, >18, 7.87, 9.11 µM for HGC-27, HT-29, HepG-2, A549, MCF7, GES-1 cells.

Cell Cycle Analysis[1]

Cell Line: HGC-27, HT-29 cells
Concentration: 0.1, 0.3, 0.9 μM
Incubation Time: 24 h
Result: Cells were arrest at the G2/M phase.

Apoptosis Analysis[1]

Cell Line: HGC-27, HT-29 cells
Concentration: 0.1, 0.3, 0.9, 2.7 μM
Incubation Time: 24 h
Result: Induced the apoptosis of HGC-27 and HT-29 cells in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: HGC-27 cells
Concentration: 0.1, 0.3, 0.9 μM
Incubation Time: 24 h
Result: Suppressed the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells.

分子量

383.42

Formula

C24H18FN3O
CAS 号

2757145-67-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hao X, et al. Design, synthesis and bioactivity evaluation of novel N-phenyl-substituted evodiamine derivatives as potent anti-tumor agents. Bioorg Med Chem. 2021; 55:116595.

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