PD-1/PD-L1-IN-14

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PD-1/PD-L1-IN-14 

PD-1/PD-L1-IN-14 (compound 17) 是 PD-1/PD-L1 相互作用的抑制剂，其IC50 值为 27.8 nM。PD-1/PD-L1-IN-14 (compound 17) 抑制PD-1/PD-L1 相互作用，促进二聚化，内吞作用并降解 PD-L1。

PD-1/PD-L1-IN-14

PD-1/PD-L1-IN-14 Chemical Structure

CAS No. : 2499965-12-5

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生物活性

PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC50 of 27.8 nM. PD-1/PD-L1-IN-14 (compound 17) inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1[1].

IC50 & Target

IC50： 27.8 nM (PD-1/PD-L1)[1].
体外研究
(In Vitro)

PD-1/PD-L1-IN-14 (compound 17) promotes cell-surface PD-L1 internalized into the cytosol and induces the degradation of PD-L1 in tumor cells through a lysosome-dependent pathway[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

400.47

Formula

C24H24N4O2
CAS 号

2499965-12-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tianyu Wang, et al. Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation. J Med Chem. 2022 Mar 10;65(5):3879-3893.

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