Anticancer agent 29

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Anticancer agent 29 

Anticancer agent 29 (Compd E/Z-6f) 是一种抗癌剂，对 CDK2、CDK1、CDK4 和 CDK6 的 IC50 值分别为 0.054 μM、0.127 μM、0.129 μM、0.396 μM。

Anticancer agent 29

Anticancer agent 29 Chemical Structure

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生物活性

Anticancer agent 29 (Compd E/Z-6f) is an anticancer agent, with IC50 values of 0.054 μM, 0.127 μM, 0.129 μM, 0.396 μM for CDK2, CDK1, CDK4 and CDK6, respectively[1].

IC50 & Target[1].

CDK2/cyclinE

0.054 μM (IC50)

CDK1/cyclinB1

0.127 μM (IC50)

CDK4

0.129 μM (IC50)

CDK6

0.396 μM (IC50)

分子量

363.81

Formula

C22H15ClFNO
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hend A A Abd El-Wahab, et al. New cell cycle checkpoint pathways regulators with 2-Oxo-indoline scaffold as potential anticancer agents: Design, synthesis, biological activities and in silico studies. Bioorg Chem. 2022 Jan 15;120:105622.

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