MM11253

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

MM11253 

MM11253 是一种有效的选择性 RARγ 拮抗剂，IC50 为 44 nM。 MM11253 对 RARα、RARβ 和 RXRα 的抑制作用较低。MM11253 阻断 RARγ 选择性激动剂的生长抑制作用。

MM11253

MM11253 Chemical Structure

CAS No. : 345952-44-5

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生物活性

MM11253 is a potent and selective RARγ antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists[1][3].

IC50 & Target[1]

RARγ

44 nM (IC50)

RARα

1000 nM (IC50)

RARβ

>1000 nM (IC50)

RXRα

>1000 nM (IC50)

体外研究
(In Vitro)

MM11253 blocks the ability of MM11254 and MM11389 to inhibit squamous cell carcinoma cell growth[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

462.67

Formula

C28H30O2S2
CAS 号

345952-44-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. M I Dawson, et al. Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition. Int J Cancer. 2001 Jan 1;91(1):8-21.

    [2]. Q Le, et al. Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids. Oncogene. 2000 Mar 9;19(11):1457-65.

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