IDO1-IN-15

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

IDO1-IN-15 

IDO1-IN-15 是一种有效的 IDO1 抑制剂 (IC50=127 nM)，在体外对抗 IDO1 酶具有与 Epacadostat 相当的效力。

IDO1-IN-15

IDO1-IN-15 Chemical Structure

CAS No. : 2126853-17-4

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生物活性

IDO1-IN-15 is a potent IDO1 inhibitor (IC50=127 nM). IDO1-IN-15 has comparable potency against IDO1 enzyme in vitro with Epacadostat[1].

IC50 & Target[1]

IDO1

127 nM (IC50)

体外研究
(In Vitro)

Cas9-IN-2 is a potent Cas9 inhibitor (IC50=246 μM), Cas9-IN-2 acts by binding to apo-Cas9 to prevent Cas9:gRNA complex formation, which can potentially be applied to modulate and control Cas9 activity in various applications[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

401.19

Formula

C13H14BrFN6O3
CAS 号

2126853-17-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wu Y, et al. Discovery of novel IDO1 inhibitors targeting the protein’s apo form through scaffold hopping from holo-IDO1 inhibitor. Bioorg Med Chem Lett. 2021;52:128373.

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