HBX 41108

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

HBX 41108 

HBX 41108 是泛素特异性蛋白酶 7 (USP7) 的非竞争性抑制剂，IC50为 424 nM。HBX 41108 抑制 USP7 介导的 p53 去泛素化以稳定 p53 并抑制癌细胞生长。HBX 41108 诱导 p53 依赖的凋亡。

HBX 41108

HBX 41108 Chemical Structure

CAS No. : 924296-39-9

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生物活性

HBX 41108 is an uncompetitive inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 424 nM. HBX 41108 inhibits USP7-mediated p53 deubiquitination to stabilize p53 and inhibits cancer cell growth. HBX 41108 induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines[1][2].

分子量

266.64

Formula

C13H3ClN4O
CAS 号

924296-39-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Colland F, et al. Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther. 2009 Aug;8(8):2286-95.

    [2]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.

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