Elomotecan hydrochloride(Synonyms: BN 80927)

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Elomotecan hydrochloride (Synonyms: BN 80927)

Elomotecan hydrochloride (BN 80927) 是一种有效的拓扑异构酶 I 和 II 抑制剂。Elomotecan hydrochloride (BN 80927) 是属于高喜树碱家族 (hCPT) 的喜树碱类似物。与其他拓扑异构酶 I 和 II 的参考抗癌药物相比，Elomotecan hydrochloride (BN 80927) 减少不同肿瘤细胞的增殖效果更好。

Elomotecan hydrochloride(Synonyms: BN 80927)

Elomotecan hydrochloride Chemical Structure

CAS No. : 220997-99-9

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生物活性

Elomotecan hydrochloride (BN 80927) is a potent inhibitor of topoisomerases I and II. Elomotecan hydrochloride (BN 80927) is a camptothecin analog belonging to the homocamptothecin family (hCPT). Elomotecan hydrochloride (BN 80927) reduces the proliferation of different tumor cells with higher potency than other anticancer drugs of reference targeting topoisomerases I and II[1].

IC50 & Target

Topoisomerase I

 

Topoisomerase II

 

分子量

558.50

Formula

C29H33Cl2N3O4
CAS 号

220997-99-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Trocóniz IF, et al. Population pharmacokinetic/pharmacodynamic modeling of drug-induced adverse effects of a novel homocamptothecin analog, elomotecan (BN80927), in a Phase I dose finding study in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2012;70(2):239-250.

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