SM-7368

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SM-7368 

SM-7368 是一种 NF-kB 抑制剂，靶向抑制下游的 MAPK p38。SM-7368 还抑制 TNF-α 诱导的 MMP-9 上调。SM-7368 可用于靶向 TNF-α 介导的肿瘤侵袭和转移的化疗研究。

SM-7368

SM-7368 Chemical Structure

CAS No. : 380623-76-7

规格 价格 是否有货 数量
5 mg ￥1100 In-stock
10 mg ￥1700 In-stock
25 mg ￥3400 In-stock
50 mg ￥5400 In-stock
100 mg   询价  
200 mg   询价  

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生物活性

SM-7368 is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation[1]. SM-7368 inhibits TNF-α-induced MMP-9 upregulation. SM-7368 can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis [2].

IC50 & Target[1][2]

NF-κB

 

MMP-9

 

p38 MAP kinase

 

体外研究
(In Vitro)

SM-7368 (5 μM) targets downstream of MAPK p38 activation in the human colon derived crypt like HT-29 and Caco-2 epithelial cell lines[1].
SM-7368 inhibits TNF-α-induced MMP-9 upregulation in a concentration-dependent manner and shows maximal activity at 10 μM. SM-7368 inhibits TNF-α-induced MMP-9 mRNA transcript accumulation and protein expression. SM-7368 strongly inhibits TNF-α-induced NF-κB activity but not AP-1 activity. SM-7368 strongly inhibits the TNF-α-induced invasion of HT1080 human fibrosarcoma cell line[2].
SM-7368 (10-25 μM) greatly inhibits TNF-α (20 ng/mL)-induced MMP-9 upregulation. 10 μM of SM-7368 almost completely abrogates this upregulation[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: HT1080 human fibrosarcoma cells
Concentration: 0, 1, 5, 10, 15, 20, and 25 μM
Incubation Time: 24 hours
Result: Greatly inhibited TNF-α (20 ng/mL)-induced MMP-9 upregulation in a concentration-dependent manner.

分子量

328.69

Formula

C10H5ClN4O5S
CAS 号

380623-76-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Sabine Kuntz, et al. Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38. Mol Nutr Food Res. 2010 Oct;54(10):1458-67.

    [2]. Ha Young Lee, et al. A small compound that inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-9 upregulation. Biochem Biophys Res Commun. 2005 Oct 21;336(2):716-22.

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