上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。
EN219
EN219 是一种特异性适中的作用于 RNF114 的 N 端半胱氨酸 C8 的合成共价配体， IC50为470 nM。EN219 抑制 RNF114 介导的自身泛素化和 p21 泛素化。
EN219 Chemical Structure
CAS No. : 380351-29-1
| 规格 | 是否有货 | ||
|---|---|---|---|
| 100 mg | 询价 | ||
| 250 mg | 询价 | ||
| 500 mg | 询价 |
* Please select Quantity before adding items.
| 生物活性 |
EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination[1]. |
|
|---|---|---|
| IC50 & Target[1] |
|
|
| 体外研究 (In Vitro) |
EN219 (1 μM; 90 min) interacts with RNF114 C8, TUBB1 C201, HSPD1 C442, and HIST1H3A C97 demonstrated by isotopic tandem orthogonal proteolysisABPP (isoTOP-ABPP) analysis[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
|
| 分子量 |
456.56 |
|
| Formula |
C17H13Br2ClN2O |
|
| CAS 号 |
380351-29-1 |
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
|
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
|
| 参考文献 |
|
所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务