Ciclopirox-d11(Synonyms: HOE296b-d11)

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Ciclopirox-d11 (Synonyms: HOE296b-d11)

Ciclopirox-d11 (HOE296b-d11) 是 Ciclopirox 的氘代物。Ciclopirox (HOE296b) 是一种合成的抗真菌剂，可用于浅表真菌病的研究。Ciclopirox olamine 具有非常广泛的活性，可抑制皮肤真菌，酵母菌，霉菌以及许多致病性革兰氏阳性和革兰氏阴性菌。

Ciclopirox-d11(Synonyms: HOE296b-d11)

Ciclopirox-d11 Chemical Structure

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生物活性

Ciclopirox-d11 (HOE296b-d11) is the deuterium labeled Ciclopirox. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

218.34

Formula

C12H6D11NO2
中文名称

环吡酮 d11
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Niewerth, M., et al., Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors. Antimicrob Agents Chemother, 2003. 47(6): p. 1805-17.

    [3]. Leem, S.H., et al., The possible mechanism of action of ciclopirox olamine in the yeast Saccharomyces cerevisiae. Mol Cells, 2003. 15(1): p. 55-61.

    [4]. Ratnavel, R.C., R.A. Squire, and G.C. Boorman, Clinical efficacies of shampoos containing ciclopirox olamine (1.5%) and ketoconazole (2.0%) in the treatment of seborrhoeic dermatitis. J Dermatolog Treat, 2007. 18(2): p. 88-96.

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