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Lasiocarpine
Lasiocarpine 是一种有肝毒性吡咯里西定生物碱 ( hepatotoxic PA)，在体内可引起致命的肝静脉闭塞性疾病。Lasiocarpine 只有在代谢转化为毒性中间体后才有毒性，包括 Dehydrolasiocarpine 和 N-oxide。
Lasiocarpine Chemical Structure
CAS No. : 303-34-4
| 规格 | 价格 | 是否有货 | |
|---|---|---|---|
| 1 mg | ￥5900 | 询问价格 & 货期 | |
| 5 mg | ￥18500 | 询问价格 & 货期 | |
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| 生物活性 |
Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide[1]. |
|---|---|
| 体外研究 (In Vitro) |
Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, known as dehydrolasiocarpine[1].Dehydrolasiocarpine and other putative didehydropyrrolizidine alkaloids (the pyrrolic esters) are very reactive,they attack nucleophilic macromolecules such as DNA and proteins, eliciting severe toxicities, including liver veno-occlusive disease and tumors[1].Lasiocarpine is mainly metabolized in vitro through five metabolic pathways, dehydrogenation, ester bond cleavage, demethylation[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
411.49 |
| Formula |
C21H33NO7 |
| CAS 号 |
303-34-4 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
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