6-Dehydrogingerdione

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

6-Dehydrogingerdione 

6-Dehydrogingerdione 通过活性氧介导 DR5 的增加，使人肝母细胞瘤 Heg2 细胞对 TRAIL 诱导的凋亡敏感。

6-Dehydrogingerdione

6-Dehydrogingerdione Chemical Structure

CAS No. : 76060-35-0

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生物活性

6-Dehydrogingerdione sensitizes human hepatoblastoma hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5[1].

体外研究
(In Vitro)

6-Dehydrogingerdione could trigger apoptotic cell death via both mitochondrial- and Fas receptor-mediated pathways[1].
6-Dehydrogingerdione (6-DG) up-regulates Ser-15 phosphorylation and evoked p53 nuclear translocation[1].
6-Dehydrogingerdione (6-DG) induces mitochondrial apoptotic pathway[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: Hep G2 cells.
Concentration: 0, 50, 100 μM.
Incubation Time: 24 h.
Result: Induced Apoptosis in Hep G2 Cells.

分子量

290.35

Formula

C17H22O4
CAS 号

76060-35-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chung-Yi Chen, et al. 6-dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5. J Agric Food Chem. 2010 May 12;58(9):5604-11.

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