PERK-IN-2

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PERK-IN-2 

PERK-IN-2 是一种高效的 PERK 抑制剂，其 IC50 值为 0.2 nM。

PERK-IN-2

PERK-IN-2 Chemical Structure

CAS No. : 1337531-83-5

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生物活性

PERK-IN-2 is a potent PERK inhibitor with an IC50 of 0.2 nM[1].

IC50 & Target

IC50: 0.2 nM (PERK)[1]
体外研究
(In Vitro)

PERK-IN-2 (0.03-0.3 μM; 2 hours) inhibits PERK autophosphorylation in A459 cells with IC50 value ranging from 0.03−0.1 μM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: A459 cells
Concentration: 0.03 μM, 0.1 μM, 0.3 μM
Incubation Time: 2 hours
Result: Inhibited PERK autophosphorylation in A459 cells.

分子量

437.42

Formula

C23H18F3N5O
CAS 号

1337531-83-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Axten JM , et al. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem. 2012 Aug 23;55(16):7193-207.

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