Neamine(Synonyms: 新霉胺) | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Neamine (Synonyms: 新霉胺)

Neamine ，一种新霉素的降解产物，是一种广谱氨基糖苷类抗生素。Neamine 是靶向血管生成素 (angiogenin) 的抗血管生成剂。Neamine 具有有效的抗菌，抗肿瘤和神经保护活性。

Neamine Chemical Structure

CAS No. : 3947-65-7

规格		是否有货
5 mg		询价
10 mg		询价
25 mg		询价

* Please select Quantity before adding items.

生物活性

Neamine, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine is an anti-angiogenesis agent targeting angiogenin. Neamine has potent antibacterial, antitumor and neuroprotective activities^[1]^[2].

体外研究
(In Vitro)

Neamine (0.625-25 μM; 48 hours; AsPC-1 cells) treatment inhibits ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in the range of 0.625-25 μM^[1].
Neamine (100 μM) also blocks the nuclear translocation of ANG effectively^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	AsPC-1 cells
Concentration:	0.625 µM, 1.25 µM, 2.5 µM, 5 µM, 10 µM, 25 µM
Incubation Time:	48 hours
Result:	Inhibited angiogenin (ANG)-induced AsPC-1 cells proliferation.

体内研究
(In Vivo)

Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells^[1]
Dosage:	30 mg/kg, 60 mg/kg
Administration:	Subcutaneous injection; daily; for 14 days
Result:	Had anti-tumor effects on AsPC-1 xenograft models.

分子量

322.36

Formula

C₁₂H₂₆N₄O₆

CAS 号

3947-65-7

中文名称

新霉胺

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Ya-Ping Liu, et al. Neamine Inhibits Growth of Pancreatic Cancer Cells in Vitro and in Vivo. J Huazhong Univ Sci Technolog Med Sci. 2016 Feb;36(1):82-87.

[2]. R Ning, et al. Neamine Induces Neuroprotection After Acute Ischemic Stroke in Type One Diabetic Rats. Neuroscience. 2014 Jan 17;257:76-85.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务