NH-bis-PEG2

发表于由

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NH-bis-PEG2 

NH-bis-PEG2 是一种不可裂解 (non-cleavable) 的 2 单元 PEG 的 ADC linker，用于抗体药物偶联物 (ADCs) 的合成。NH-bis-PEG2 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。

NH-bis-PEG2

NH-bis-PEG2 Chemical Structure

CAS No. : 54384-47-3

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生物活性

NH-bis-PEG2 is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH-bis-PEG2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

IC50 & Target

Non-cleavable

 

PEGs

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

193.24

Formula

C8H19NO4
CAS 号

54384-47-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Brown A, et al. PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder. Sci Rep. 2016 Aug 30;6:31750.

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