Propargyl-PEG3-acid

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Propargyl-PEG3-acid  纯度: ≥98.0%

Propargyl-PEG3-acid是一种不可降解 (non-cleavable) 的含 3 个单元 PEG 的 ADC linker，同时也是基于PEG的PROTAC linker,可用于合成6-OHDA-PEG3-yne。6-OHDA-PEG3-yne 包含6-OHDA (HY-B1081, HY-B1081A) 和Propargyl-PEG3-acid。

Propargyl-PEG3-acid

Propargyl-PEG3-acid Chemical Structure

CAS No. : 1347760-82-0

规格 价格 是否有货 数量
25 mg ￥600 In-stock
50 mg ￥1000 In-stock
100 mg ￥1500 In-stock
200 mg   询价  
500 mg   询价  

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生物活性

Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA (HY-B1081, HY-B1081A) and Propargyl-PEG3-acid[1].

IC50 & Target

PEGs

 

Non-cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

216.23

Formula

C10H16O5
CAS 号

1347760-82-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Farzam A, et al. A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death. Redox Biol. 2020 Jan;28:101377.

    [2]. Albone, Earl F, et al. ERIBULIN-BASED ANTIBODY-DRUG CONJUGATES AND METHODS OF USE. Patent. 20170252458.

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