HEMADO

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HEMADO 

HEMADO 是一种有效的，选择性腺苷 A3 受体激动剂，对人 A3 亚型的 Ki 值为 1.1 nM。

HEMADO

HEMADO Chemical Structure

CAS No. : 403842-38-6

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生物活性

HEMADO is a potent and selective adenosine A3 receptor agonist with a Ki of 1.1 nM at the human A3 subtype[1].

IC50 & Target

Ki: 1.1 nM (human A3 subtype)[1]
体外研究
(In Vitro)

HEMADO (compound 8a) has Kis of 327 nM and 1230 nM for A1 and A2A and a EC50 of 100 μM for A2B receptors[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

361.40

Formula

C17H23N5O4
CAS 号

403842-38-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Klotz KN, et al. [3H]HEMADO— a novel tritiated agonist selective for the human adenosine A3 receptor. Eur J Pharmacol. 2007 Feb 5;556(1-3):14-8. Epub 2006 Oct 27.

    [2]. Volpini R, et al. N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. J Med Chem. 2002 Jul 18;45(15):3271-9.

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