Phthalimide-PEG3-C2-OTs

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Phthalimide-PEG3-C2-OTs 

Phthalimide-PEG3-C2-OTs (Compound 5) 是一种 PROTAC linker，属于 PEG 类。Phthalimide-PEG3-C2-OTs 可用于合成一系列 PROTAC 分子。PROTAC 分子含有两个通过 linker 连接的不同配体; 一种是 E3 泛素连接酶配体，另一种是靶蛋白配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。

Phthalimide-PEG3-C2-OTs

Phthalimide-PEG3-C2-OTs Chemical Structure

CAS No. : 382162-12-1

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生物活性

Phthalimide-PEG3-C2-OTs (Compound 5) is a PROTAC linker, which refers to the PEGs composition. Phthalimide-PEG3-C2-OTs can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC50 & Target[1]

PEGs

 

分子量

477.53

Formula

C23H27NO8S
CAS 号

382162-12-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Stegmaier P, et al. Photoactive branched and linear surface architectures for functional and patterned immobilization of proteins and cells onto surfaces: a comparative study. Chemphyschem. 2009 Feb 2;10(2):357-69.

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