Cyclophosphamide-d8 hydrate(Synonyms: 环磷酰胺水合物 d8 (hydrate))

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Cyclophosphamide-d8 hydrate (Synonyms: 环磷酰胺水合物 d8 (hydrate))

Cyclophosphamide-d8 hydrate 是 Cyclophosphamide hydrate 的氘代物。Cyclophosphamide hydrate 是一种合成的 DNA Alkylator，在化学上与氮芥类有关，具有抗肿瘤及免疫抑制活性。

Cyclophosphamide-d8 hydrate(Synonyms: 环磷酰胺水合物 d8 (hydrate))

Cyclophosphamide-d8 hydrate Chemical Structure

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生物活性

Cyclophosphamide-d8 hydrate is the deuterium labeled Cyclophosphamide hydrate. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

287.15

Formula

C7H9D8Cl2N2O3P
中文名称

环磷酰胺水合物 d8 (hydrate)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Schwartz PS, et al. Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. Mol Pharmacol. 2001 Dec;60(6):1268-1279.

    [3]. Liu P, et al. Administration of cyclophosphamide changes the immune profile of tumor-bearing mice. J Immunother. 2010 Jan;33(1):53-9.

    [4]. al-Jafari AA, et al. Inhibition of human acetylcholinesterase by cyclophosphamide. Toxicology. 1995 Jan 19;96(1):1-6.

    [5]. Harris RN, et al. Carbon tetrachloride-induced increase in the antitumor activity of cyclophosphamide in mice: a pharmacokineticstudy. Cancer Chemother Pharmacol. 1984;12(3):167-72.

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