上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。
AUTAC1
AUTAC1是一种 MetAP2 靶向自噬介导降解体 (AUTAC)。AUTACs 包含一个降解标签和一个弹头确保靶向特异性。AUTAC1 包含一个 FBnG 和一个 Fumagillol 部分。Fumagillol 共价结合到 MetAP2 上。
AUTAC1 Chemical Structure
| 规格 | 是否有货 | ||
|---|---|---|---|
| 100 mg | 询价 | ||
| 250 mg | 询价 | ||
| 500 mg | 询价 |
* Please select Quantity before adding items.
| 生物活性 |
AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC). AUTACs contain a degradation tag and a warhead to provide target specificity. AUTAC1 contains an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety. Fumagillol binds covalently to MetAP2[1]. |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 体外研究 (In Vitro) |
AUTAC1 (1-100 μM, 24 h) silences endogenous MetAP2 in hela cells[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[1]
|
||||||||
| 分子量 |
931.08 |
||||||||
| Formula |
C44H63FN8O11S |
||||||||
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
||||||||
| 参考文献 |
|
所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务