GSK1795091(Synonyms: CRX-601)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

GSK1795091 (Synonyms: CRX-601)

GSK1795091，一种免疫刺激剂，是一种合成的 TLR4 激动剂。具有抗肿瘤活性。GSK1795091 可用作疫苗佐剂，以增强对流感病毒疫苗的粘膜和系统免疫。

GSK1795091(Synonyms: CRX-601)

GSK1795091 Chemical Structure

CAS No. : 1233589-81-5

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生物活性

GSK1795091 (CRX-601), an immunologic stimulator, is a synthetic TLR4 agonist. Antitumor activity. GSK1795091 can be used as a vaccine adjuvant to enhance both mucosal and systemic immunity to influenza virus vaccines[1][2].

分子量

1446.09

Formula

C81H157N2O16P
CAS 号

1233589-81-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hug BA, et al. Safety, Pharmacokinetics, and Pharmacodynamics of the TLR4 Agonist GSK1795091 in Healthy Individuals: Results from a Randomized, Double-blind, Placebo-controlled, Ascending Dose Study. Clin Ther. 2020;42(8):1519-1534.e33.

    [2]. Maroof A, et al. Intranasal vaccination promotes detrimental Th17-mediated immunity against influenza infection. PLoS Pathog. 2014;10(1):e1003875.

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