Compound 48/80(Synonyms: Poly-p-methoxyphenethylmethylamine)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Compound 48/80 (Synonyms: Poly-p-methoxyphenethylmethylamine)

Compound 48/80 (Poly-p-methoxyphenethylmethylamine) 作为选择性肥大细胞激活剂广泛用于动物和组织模型。Compound 48/80 作用于肥大细胞膜，刺激三聚体 G 蛋白，并通过磷脂酶 C 和 D 途径诱导脱颗粒。

Compound 48/80(Synonyms: Poly-p-methoxyphenethylmethylamine)

Compound 48/80 Chemical Structure

CAS No. : 94724-12-6

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Compound 48/80 的其他形式现货产品:

Compound 48/80 trihydrochloride

生物活性

Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a “selective” mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways[1][2].

IC50 & Target

Mast Cell Activator[1]
体外研究
(In Vitro)

Compound 48/80 (poly-p-methoxyphenethylmethylamine), an agent commonly used to trigger degranulation of mast cells, at concentrations of 5-20 μg/ml suppresses the proliferation of L1210 and Friend leukemic cells in vitro, inducing the formation of giant cells, which are polykaryons[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

519.72

Formula

C32H45N3O3
CAS 号

94724-12-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104.

    [2]. Wang YH, Taché Y, Harris AG, Kreutner W, Daly AF, Wei JY. Desloratadine prevents compound 48/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique. Allergy. 2005;60(1):117-124.

    [3]. Darzynkiewicz Z, Carter S. Compound 48/80 impairs cytokinesis in murine leukemic cells. J Cell Physiol. 1984;119(1):1-6.

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