TH5427 hydrochloride

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

TH5427 hydrochloride 

TH5427 hydrochloride 是一种有效的选择性 NUDT5 抑制剂 (IC50=29 nM)。TH5427 hydrochloride 对 NUDT5 的选择性比 MTH1 高 690 倍。TH5427 hydrochloride 阻断乳腺癌细胞孕激素依赖性、PAR 衍生的核 ATP 合成及随后的染色质重塑、基因调控和增殖。

TH5427 hydrochloride

TH5427 hydrochloride Chemical Structure

CAS No. : 2253744-57-7

规格 价格 是否有货
5 mg ￥1200 询问价格 & 货期
10 mg ￥2000 询问价格 & 货期
25 mg ￥4200 询问价格 & 货期
50 mg ￥6800 询问价格 & 货期
100 mg ￥11500 询问价格 & 货期

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生物活性

TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells[1].

体外研究
(In Vitro)

TH5427 hydrochloride inhibits progestin-dependent nuclear ATP synthesis in breast cancer cells. TH5427 hydrochloride significantly disrupted EGFR and MMTV-luc expression following progestin stimulation. TH5427 hydrochloride abrogates the progestin-dependent proliferation response in T47DWT cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

527.79

Formula

C20H21Cl3N8O3
CAS 号

2253744-57-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Page BDG, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells [published correction appears in Nat Commun. 2019 Nov 1;10(1):5050]. Nat Commun. 2018;9(1):250. Published 2018 Jan 17.

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