ARQ 621

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ARQ 621  纯度: ≥99.0%

ARQ 621 是一种变构的有效的选择性 Eg5 抑制剂，Eg5 是一种参与细胞分裂的基于微管的 ATPase 运动蛋白。ARQ 621 具有抗肿瘤活性。ARQ 621 是一种驱动蛋白 (kinesin) 抑制剂。

ARQ 621

ARQ 621 Chemical Structure

CAS No. : 1095253-39-6

规格 价格 是否有货 数量
1 mg ￥2400 In-stock
5 mg   询价  
10 mg   询价  

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生物活性

ARQ 621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. Anti-tumor activity[1]. ARQ 621 is a kinesin inhibitor[2].

IC50 & Target[1]

Eg5

 

体外研究
(In Vitro)

Over-expression of Eg5 causes genomic instability and tumor formation in mice; therefore, Eg5 is a potential anti-cancer target[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

552.43

Formula

C28H24Cl2FN5O2
CAS 号

1095253-39-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献

  • [1]. L. C. Chen, et al. First-in-human study with ARQ 621, a novel inhibitor of Eg5: Final results from the solid tumors cohort.J Clin Oncol. 2011, May (20): 3076-3076.

    [2]. Lindsay S Roberts, et al. Mapping Novel Metabolic Nodes Targeted by Anti-Cancer Drugs that Impair Triple-Negative Breast Cancer Pathogenicity. ACS Chem Biol. 2017 Apr 21;12(4):1133-1140.

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