Tubulin polymerization-IN-16

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Tubulin polymerization-IN-16 

Tubulin aggregation-IN-16 (compound 5g) 是一种有效的tubulin 聚合抑制剂。Tubulin aggregation-IN-16 对癌细胞最有效，IC50 值为 0.084-0.221 μM。Tubulin 聚合-IN-16 可有效破坏微管/微管蛋白动力学，在 SGC-7901 细胞中诱导 G2/M 期细胞周期停滞。

Tubulin polymerization-IN-16

Tubulin polymerization-IN-16 Chemical Structure

CAS No. : 2296731-38-7

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生物活性

Tubulin polymerization-IN-16 (compound 5g) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-16 shows most potent against cancer cells, with IC50 values of 0.084-0.221 μM. Tubulin polymerization-IN-16 potently disrupts microtubule/tubulin dynamics, induces cell cycle arrest at G2/M phase in SGC-7901 cells[1].

分子量

465.50

Formula

C24H27N5O5
CAS 号

2296731-38-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Huang L, et al. Design, synthesis and bio-evaluation of novel 2-aryl-4-(3,4,5-trimethoxy-benzoyl)-5-substituted-1,2,3-triazoles as the tubulin polymerization inhibitors. Eur J Med Chem. 2020;186:111846.

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