SU11652

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SU11652 

SU11652 是一种有效的酪氨酸激酶受体 (RTK) 抑制剂。SU11652 也抑制 RTKs 分裂激酶家族的几个成员，包括 VEGFR, FGFR, PDGFR, 和 Kit。SU11652 可用于表达 Kit 突变的自发癌症的研究。

SU11652

SU11652 Chemical Structure

CAS No. : 326914-10-7

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生物活性

SU11652 is a potent receptor tyrosine kinase (RTK) inhibitor. SU11652 also inhibits several members of the split kinase family of RTKs, including VEGFR, FGFR, PDGFR, and Kit. SU11652 can be uesd for spontaneous cancers expressing Kit mutations research[1].

IC50 & Target

IC50: 0.01 μM (PDGFR), 0.03 μM (Flk-1), 0.05 μM (c-kit)[1]
体外研究
(In Vitro)

SU11652 (0-1 μM, 0-72 h) inhibits the growth of mast cell lines expressing mutant Kit[1].
SU11652 (0-1 μM, 0-72 h) induces cell cycle arrest followed by apoptosis in cell lines expressing mutant Kit[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

414.93

Formula

C22H27ClN4O2
CAS 号

326914-10-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Liao AT, et al. Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. Blood. 2002;100(2):585-593.

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