IRAK4-IN-15

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

IRAK4-IN-15 

IRAK4-IN-15 (compound 35) 是一种有效的选择性 IRAK4 抑制剂，IC50 为 0.002 µM。IRAK4-IN-15 显示出良好的人类 PK 预测且具有低内在清除率。IRAK4-IN-15 与 Acalabrutinib 联用显示出对 MyD88/CD79 双突变体 ABC-DLBCL 的显著协同体外活性。

IRAK4-IN-15

IRAK4-IN-15 Chemical Structure

CAS No. : 2667681-85-6

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生物活性

IRAK4-IN-15 (compound 35) is a potent and selective IRAK4 inhibitor with an IC50 of 0.002 µM. IRAK4-IN-15 shows good human PK predictions with low intrinsic clearance. IRAK4-IN-15 shows great synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib. [1].

IC50 & Target[1]

IRAK4

0.002 μM (IC50)

体外研究
(In Vitro)

IRAK4-IN-15 (compound 35) shows cell pIRAK4 potencies with an IC50 of 0.21 µM[1].
IRAK4-IN-15 (compound 35) shows selectivity with IC50s of 0.002,1.2, >10,1.5, 0.23, 0.48, 0.93, 0.57 µM for IRAK4, IRAK1, BTK, Flt3, PI3Kδ, TRKa, TRKb, TRKc, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

488.56

Formula

C25H29FN10
CAS 号

2667681-85-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Degorce SL, et al. Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors. Bioorg Med Chem. 2020 Dec 1;28(23):115815.

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