HDAC-IN-39

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

HDAC-IN-39 

HDAC-IN-39 (化合物 16c) 是一种有效的 HDAC 抑制剂，其 IC50 值分别为 1.07 μM (HDAC1)、1.47 μM (HDAC2) 和 2.27 μM (HDAC3)。HDAC-IN-39 对微管聚合也有明显抑制作用。HDAC-IN-39 诱导细胞周期阻滞在 G2/M 期。HDAC-IN-39 对耐药癌细胞显示出良好的抗癌活性。

HDAC-IN-39

HDAC-IN-39 Chemical Structure

CAS No. : 2414046-33-4

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生物活性

HDAC-IN-39 (compound 16c) is a potent HDAC inhibitor, with IC50 values of 1.07 μM (HDAC1), 1.47 μM (HDAC2), and 2.27 μM (HDAC3), respectively. HDAC-IN-39 also significantly inhibits microtubule polymerization. HDAC-IN-39 induces cell cycle arrest at the G2/M phase. HDAC-IN-39 displays promising anticancer activity against resistant cancer cells[1].

IC50 & Target

HDAC1

1.07 μM (IC50)

HDAC2

1.47 μM (IC50)

HDAC3

2.27 μM (IC50)

HDAC8

>10 μM (IC50)

分子量

502.58

Formula

C27H26N4O4S
CAS 号

2414046-33-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wu WC, et al. Design, synthesis, and evaluation of N-phenyl-4-(2-phenylsulfonamido)-benzamides as microtubule-targeting agents in drug-resistant cancer cells, displaying HDAC inhibitory response. Eur J Med Chem. 2020 Apr 15;192:112158.

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