BLK-IN-3

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

BLK-IN-3 

BLK-IN-3 (Compound 1) 是一种有效的 BLK 抑制剂,IC50 为 18.8 nM。B 淋巴酪氨酸激酶 (BLK) 是 SRC 家族非受体酪氨酸激酶的成员,参与 B 细胞受体 (BCR) 信号通路和 B 细胞发育和功能。BLK-IN-3 具有研究癌症疾病的潜力。

BLK-IN-3

BLK-IN-3 Chemical Structure

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生物活性

BLK-IN-3 (Compound 1) is a potent inhibitor of BLK with an IC50 of 18.8 nM. B-lymphoid tyrosine kinase (BLK), a member of the SRC family nonreceptor tyrosine kinase, is involved in the B-cell receptor (BCR) signaling pathway and B cell development and function. BLK-IN-3 has the potential for the research of cancer diseases[1].

分子量

560.53

Formula

C29H23F3N6O3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Fu T, et al. Discovery of selective irreversible inhibitors of B-Lymphoid tyrosine kinase (BLK). Eur J Med Chem. 2022 Feb 5;229:114051.

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