EIPA hydrochloride(Synonyms: L593754 hydrochloride; MH 12-43 hydrochloride)

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EIPA hydrochloride (Synonyms: L593754 hydrochloride; MH 12-43 hydrochloride) 纯度: 99.92%

EIPA hydrochloride (L593754 hydrochloride) 是一种 TRPP3 channel 抑制剂，其 IC50 值为 10.5 μM。EIPA hydrochloride 还抑制 Na+/H+ 交换器 (NHE) 和巨噬细胞。

EIPA hydrochloride(Synonyms: L593754 hydrochloride; MH 12-43 hydrochloride)

EIPA hydrochloride Chemical Structure

CAS No. : 1345839-28-2

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥1089 In-stock
5 mg ￥990 In-stock
10 mg ￥1600 In-stock
50 mg   询价  
100 mg   询价  

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EIPA hydrochloride 相关产品

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生物活性

EIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosis[1][2][3].

IC50 & Target

IC50: 10.5 μM (TRPP3 channel)[1]
NHE[2]
Macropinocytosis[3]
分子量

336.22

Formula

C11H19Cl2N7O
CAS 号

1345839-28-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

DMSO : 130 mg/mL (386.65 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9742 mL 14.8712 mL 29.7424 mL
5 mM 0.5948 mL 2.9742 mL 5.9485 mL
10 mM 0.2974 mL 1.4871 mL 2.9742 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Dai XQ, et al. Inhibition of TRPP3 channel by MK-870 and analogs. Mol Pharmacol. 2007 Dec;72(6):1576-85.

    [2]. Shi H, et al. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017;42(6):2418-2429.

    [3]. Zhu BY, et al. A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis.

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