红霉素
基本信息
产品名称 | 红霉素 |
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英文名称 | Erythromycin |
别名 | 红霉素;红霉素碱 |
英文别名 | (-)-Erythromycin ;Abomacetin |
规格或纯度 | 效价 ≥850 μg/mg |
运输条件 | 常规运输 |
生化机理 | 在转肽步骤抑制延长期,靠结合到核糖体上抑制细菌蛋白合成,对细菌诱发红霉素抗性。抗菌谱: 革兰氏阴性和阳性细菌。 属大环内酯抗生素(Macrolide antibiotic) .大环内酯类抗生素。抑制细胞色素p450 3A4和P-糖蛋白。结合50S核糖体亚基并抑制革兰氏阳性和革兰氏阴性细菌中的蛋白质合成。 |
一般描述
Erythromycin is a potent macrolide inhibitor of CYP3A4 with antiinflammatory and prokinetic properties. Macrolides belong to a group of antibiotics that bind to the 50S ribosomal subunit and inhibit protein synthesis. Erythromycin is derived from Streptomyces erythreus and has been shown to inhibit NF-κB transcriptional activation, which leads to the inhibition of cytokine gene expression of IL-8 and lL-6. This mechanism was shown to occur via calcineruin-independent signaling T lymphocytes. A macrolide antibiotic protein synthesis inhibitor. Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjμgate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.
Erythromycin is a potent macrolide inhibitor of CYP3A4 with antiinflammatory and prokinetic properties. Macrolides belong to a group of antibiotics that bind to the 50S ribosomal subunit and inhibit protein synthesis. Erythromycin is derived from Streptomyces erythreus and has been shown to inhibit NF-κB transcriptional activation, which leads to the inhibition of cytokine gene expression of IL-8 and lL-6. This mechanism was shown to occur via calcineruin-independent signaling T lymphocytes.
A macrolide antibiotic protein synthesis inhibitor. Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.
相关属性
CAS编号 | 114-07-8 |
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敏感性 | 对湿度敏感 |
比旋光度 | -74 ° (C=2, EtOH) |
熔点 | 138-140°C |
溶解性 | 熔于乙醇、甲醇、丙酮、氯仿、乙腈和乙酸乙酯,中等程度溶于醚、二氯甲烷和乙酸戊酯。难溶于水。微有引湿性,无臭,味苦。遇酸不稳定。水中溶解度:+/- 3 MG/ML。 |
储存温度 | 充氩 |
RTECS | KF437500 |
MDL号 | MFCD00084654 |
密度 | 1.2 |
分子量 | 733.93 |
分子式 | C37H67NO13 |
EC号 | 204-040-1 |
品牌 | Jinpan |
备注 | 如果有可能,您尽量在同一天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
PubChem CID | 12560 |