Levomefolic acid(Synonyms: 5-甲基四氢叶酸; 5-MTHF)

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Levomefolic acid (Synonyms: 5-甲基四氢叶酸; 5-MTHF) 纯度: 98.55%

Levomefolic acid (5-MTHF)是天然的叶酸活性形式。

Levomefolic acid(Synonyms: 5-甲基四氢叶酸; 5-MTHF)

Levomefolic acid Chemical Structure

CAS No. : 31690-09-2

规格 价格 是否有货 数量
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10 mM * 1 mL in Water ￥1551 In-stock
2 mg ￥1020 In-stock
5 mg ￥1534 In-stock
10 mg ￥2700 In-stock
50 mg ￥11253 In-stock
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生物活性

Levomefolic acid (5-MTHF) is the natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. IC50 value: Target: Folate analog Levomefolic acid has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. Levomefolic acid (5-MTHF) has the prominent antioxidant activity. A high dose of 5-MTHF or folic acid does not influence Natural killer (NK) cell function in vitro.

Clinical Trial

分子量

459.46

Formula

C20H25N7O6
CAS 号

31690-09-2
中文名称

5-甲基四氢叶酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : 5 mg/mL (10.88 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1765 mL 10.8823 mL 21.7647 mL
5 mM 0.4353 mL 2.1765 mL 4.3529 mL
10 mM 0.2176 mL 1.0882 mL 2.1765 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Hirsch S, et al. Natural killer cell cytotoxicity is not regulated by folic acid in vitro. Nutrition. 2013 Jan 9. pii: S0899-9007(12)00404-2.

    [2]. Liu Y, Green TJ, Wong P, Kitts DD. Microencapsulation of L-5-methyltetrahydrofolic Acid with ascorbate improves stability in baked bread products. J Agric Food Chem. 2013 Jan 9;61(1):247-54.

    [3]. Merola N, Alonso FJ, Ros G, Castón MJ. Antioxidant activity comparison between [6S]-5-methyltetrahydrofolic acid calcium salt and the related racemate form. Food Chem. 2013 Jan 15;136(2):984-8.

    [4]. Liu Y, Tomiuk S, Rozoy E, et al. Thermal oxidation studies on reduced folate, L-5-methyltetrahydrofolic acid (L-5-MTHF) and strategies for stabilization using food matrices. J Food Sci. 2012 Feb;77(2):C236-43.

    [5]. Bashir M Rezka, Guido R.M.M Haenena, Wim J.F van der Vijgha, et al. Tetrahydrofolate and 5-methyltetrahydrofolate are folates with high antioxidant activity. Identification of the antioxidant pharmacophore. 2003,555(3):601-605.

    [6]. Levomefolic acid

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