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SCH 58261 纯度: 99.78%
SCH 58261 是一种强效、选择性的竞争性腺苷 A2A 受体拮抗剂,IC50 值为 15 nM,对 A2A 受体的选择性分别是 A1、A2B 和 A3 受体的 323 倍、53 倍、100 倍。
![SCH 58261 Chemical Structure SCH 58261](http://www.fluoroprobe.com/wp-content/uploads/2022/05/hy-19533.gif)
SCH 58261 Chemical Structure
CAS No. : 160098-96-4
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥858 | In-stock | |
5 mg | ¥780 | In-stock | |
10 mg | ¥1550 | In-stock | |
50 mg | ¥5900 | In-stock | |
100 mg | ¥9950 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
SCH 58261 相关产品
•相关化合物库:
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- Neurodegenerative Disease-related Compound Library
生物活性 |
SCH 58261 is a potent, selective and competitive antagonist of adenosine A2A receptor with an IC50 of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively[1][2][3]. |
IC50 & Target |
IC50: 15 nM (A2A receptor)[2] |
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体外研究 (In Vitro) |
SCH 58261 (0 nM–10 µM; 7 days) decreases cell viability in a concentration-dependent in the NSCLC cell line H1975[4]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[4]
Cell Proliferation Assay[5]
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体内研究 (In Vivo) |
SCH 58261 (2 mg/kg; i.p.; daily; for 20 days) causes a decrease in the tumor burden in a NSCLC mouse model[5]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
345.36 |
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Formula |
C18H15N7O |
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CAS 号 |
160098-96-4 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 34 mg/mL (98.45 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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