盐酸四环素
基本信息
| 产品名称 | 盐酸四环素 |
|---|---|
| 英文名称 | Tetracycline hydrochloride |
| 别名 | 四环素 盐酸盐 |
| 英文别名 | 2-naphthacenecarboxamid |
| 规格或纯度 | 96% |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | Mode of Action: Tetracycline passively diffuses throμgh proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, sμggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drμg, that is responsible for antibacterial action. Mode of Resistance: The effects are inactivated via a loss of cell wall permeability. Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria. |
一般描述
Tetracycline Hydrochloride belongs to a family of broad-spectrum antibiotics that inhibit protein synthesis in bacteria by blocking the binding of aminoacyl-tRNA to the bacterial ribosome and has been used in a variety of root canal studies. In tick-borne encephalitis virus (TBEV) studies, tetracycline hydrochloride increased the concentrations of sIL-6R, IL-1RA, sTNFR1 and decreased the levels of TNF-α. Studies show that tetracycline can induce cold shock response and enhance expression of P450 proteins.作用模式: 靠阻止胺酰基-tRNA至核糖体30S亚单位上阻止蛋白的合成。 抗菌谱:革兰氏阴性和阳性细菌。 阻断模式: 细胞壁渗透性缺失。
Tetracycline Hydrochloride belongs to a family of broad-spectrum antibiotics that inhibit protein synthesis in bacteria by blocking the binding of aminoacyl-tRNA to the bacterial ribosome and has been used in a variety of root canal studies. In tick-borne encephalitis virus (TBEV) studies, tetracycline hydrochloride increased the concentrations of sIL-6R, IL-1RA, sTNFR1 and decreased the levels of TNF-α. Studies show that tetracycline can induce cold shock response and enhance expression of P450 proteins.
Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug resistance and potential side effects including acute pancreatitis. It is recommended for use in cell culture applications at 10 mg/L.
相关属性
| CAS编号 | 64-75-5 |
|---|---|
| 敏感性 | 对光、热及空气敏感 |
| 比旋光度 | -253° (C=0.5,0.1mol/L HCl) |
| 熔点 | 223°C |
| 溶解性 | Soluble in water, dimethyl sulfoxide, methanol and ethanol. Insoluble in ether and hydrocarbons. |
| 储存温度 | -20°C储存,充氩 |
| MDL号 | MFCD00078142 |
| 密度 | 1.177 |
| 分子量 | 480.9 |
| 分子式 | C22H24N2O8·HCl |
| EC号 | 200-593-8 |
| 品牌 | Jinpan |