卡萨霉素B
基本信息
| 产品名称 | 卡萨霉素B |
|---|---|
| 英文名称 | Kazusamycin B |
| 规格或纯度 | >95% |
| 运输条件 | 超低温冰袋运输 |
一般描述
卡萨霉素B 是瘦链霉菌素复合物的次要成分，该复合物是由a.Streptomyces sp。|的肉汤发酵产生的。该化合物是Leptomycin A的羟基化类似物，它是一种核输出抑制剂，且具有高度亲脂性。| 卡萨霉素B 对肿瘤L1210，P388 / S，B16，HeLa S3，L5178Y-ML或当在卡祖霉素B存在下培养72小时时，确定L929的IC 50为1.8、2.0、0.7、1.8、10.0和1.0ng / ml。该化合物在小鼠中还表现出广泛的抗肿瘤活性，其有效性比体内和体外给药浓度更依赖于给药方案。
Kazusamycin B is a minor component of the leptomycin complex produced from the fermentation of the broth of a|Streptomyces sp.|. The compound is a hydroxylated analogue of Leptomycin A , a nuclear export inhibitor, and highly lipophillic.|In vitro|antitumor activity of Kazusamycin B on tumors L1210, P388/S, B16, HeLa S3, L5178Y-ML or L929 was ascertained to have an IC|50|of 1.8, 2.0, 0.7, 1.8, 10.0 and l.0 ng/ml when cultured in the presence of Kazusamycin B for 72 hours. The compound has also displayed broad antitumor activity in mice with effectiveness being more dependent on dosing regimen than dosing concentration both|in vivo|and|in vitro|. Kazusamycin B also possesses antibacterial and antifungal activity.
相关属性
| CAS编号 | 107140-30-7 |
|---|---|
| 溶解性 | Soluble in ethanol, methanol, DMSO, and DMF. |
| 储存温度 | -20°C储存 |
| RTECS | OA0551000 |
| 分子量 | 542.7 |
| 分子式 | C₃₂H₄₆O₇ |
| 品牌 | Jinpan |
| Smiles | CC1C=CC(=O)OC1/C=C/C(=C\\C(C)C/C=C/C(=C/C(CO)C(=O)C(C)C(C(C)C/C(=C/C(=O) O)/C)O)/C)/C |
| IC50 | B16: IC₅₀= 0.7 ng/ml; L929: IC₅₀= 1.0 ng/ml; Tumors L1210: IC₅₀= 1.8 ng/ml; HeLa S3: IC₅₀= 1.8 ng/ml; P388/S: IC₅₀= 2.0 ng/ml |
| PubChem CID | 6436293 |