Δ12-PGJ2（Δ12-前列腺素J2）
PGD2的分解产物，显示出有效的抗病毒和抗增殖活性
A solution in methyl acetate,98%
有货
基本信息
| 产品名称 | Δ12-PGJ2（Δ12-前列腺素J2） |
|---|---|
| 英文名称 | Δ12-PGJ2 (Δ12-Prostaglandin J2) |
| 规格或纯度 | A solution in methyl acetate,98% |
| 运输条件 | 超低温冰袋运输 |
一般描述
δ12-PGJ2（δ12-前列腺素J2）是PGD2的分解产物，具有强大的抗病毒和抗增殖活性。还已经显示该化合物诱导细胞凋亡，并抑制磷酸肌醇转换。与谷胱甘肽结合被认为可增强δ12-PGJ2的细胞毒性。与其他前列腺素相似，通常很难区分直接源自“亲本”分子的生物活性和源自其代谢产物的生物活性。
δ12-PGJ2 (δ12-Prostaglandin J2) is a decomposition product of PGD2 that has shown potent antiviral and anit-proliferative activity. This compound has also been shown to induce apoptosis, and to inhibit phosphoinositide turnover. Conjugation with glutathione is thought to enhance the cytotoxicity of δ12-PGJ2. Similar to other prostaglandins, it is often difficult to distinguish between biological activities derived directly from ′parent′ molecules and those derived from metabolites thereof.
相关属性
| CAS编号 | 87893-54-7 |
|---|---|
| 折光率 | n20D1.56 |
| pKa值 | pKₐ: 4.75 |
| 溶解性 | Soluble in ethanol (>25 mg/ml), DMSO (>25 mg/ml), and acetone. |
| 储存温度 | -80℃储存 |
| 分子量 | 334.5 |
| 分子式 | C₂₀H₃₀O₄ |
| 品牌 | Jinpan |
| Smiles | CCCCC[C@@H](C/C=C/1\\[C@H](C=CC1=O)C/C=C\\CCCC(=O)O)O |
| IC50 | growth of cultured L1210: IC₅₀= 0.7 μg/ml; mPGES1: IC₅₀= 64 μM |
| PubChem CID | 5280885 |