Saccharocarcin A

Saccharocarcin A 是一种不寻常的四氢叶酸，在结构上与奇异霉素，氯霉素，四叶素和维司他汀有关，对革兰氏阳性菌和沙眼衣原体具有明显的活性。有限的供应量限制了该代谢物在文献中的进一步研究，但是，该类别的一些成员受到了相当多的文献关注。Versipelostatin已显示抑制GRP78启动子的转录，该基因在葡萄糖剥夺下作为应激信号通路的一部分被激活，导致未折叠的蛋白应答（UPR）。仅在葡萄糖剥夺的情况下才观察到UPR抑制作用，并且其导致葡萄糖剥夺的细胞的选择性和大量杀伤。Tetrocarcin A

Saccharocarcin A is an unusual tetronic acid structurally related to kijanimicin, chlorothricin, tetrocarcins and versipelostatin which has pronounced activity against Gram positive bacteria and Chlamydia trachomatis. Limited availability has restricted further investigation of this metabolite in the literature, however, several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signaling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3′-kinase/Akt signaling pathway.