Gilvocarcin V

Gilvocarcin V是从链霉菌属（Streptomyces sp）分离的C-糖苷抗肿瘤活性物质复合物的主要类似物。Gilvocarcin V在8位上含有一个乙烯基，是该复合物最有效的类似物。人们认为它可以作为人拓扑异构酶II的催化活性的抑制剂。代谢物显示出强大的抗菌，抗真菌，抗病毒和抗肿瘤活性。关于gilvocarcins的最新研究表明，它们充当了DNA与组蛋白的光活化交联剂。Gilvocarcin V还被证明对革兰氏阳性细菌具有细胞毒性。介导DNA与组氨酸H3之间的独特交联反应。并且显示出对革兰氏

Gilvocarcin V is the major analogue of a complex of C-glycoside antitumor actives isolated from a Streptomyces sp. Gilvocarcin V contains a vinyl group in the 8-position and is the most potent analogue of the complex. It is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. The metabolite displays potent antibacterial, antifungal, antiviral and antitumor activity. Recent research on the gilvocarcins suggests that they act as photoactivated crosslinkers of DNA to histones. Gilvocarcin V has also been shown to be cytotoxic against Gram-positive bacteria. Mediates a unique cross-linking reaction between DNA and histidine H3. And is shown to be weakly active against Gram-negative bacteria, fungi and tumors. Also an antineoplastic and a photosensitizing compound.