寡霉素
基本信息
| 产品名称 | 寡霉素 |
|---|---|
| 英文名称 | Oligomycin |
| 别名 | Oligomycin |
| 英文别名 | Oligomycin a, b, c mixture;Oligomycin Complex |
| 规格或纯度 | 90% |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | Macrolide antibiotic; inhibits mitochondrial ATPase and phosphoryl group transfer.ATP synthase inhibitor. Blocks the proton channel (F o subunit). Macrolide antibiotic. |
一般描述
Oligomycin is a macrolide that acts as a specific inhibitor of the mitochondrial ATP-synthase and blocks oxidative phosphorylation. The compound is a mixture of isomers A ,B , and C .Cancer cell studies show that Oligomycin does not activate the hypoxia-induced factor, however, it enhances the bioenergetic adaptation of heterogeneous bioenergetically organized cells. Oligomycin has been shown to decreased the cyclin D1 protein expression levels
Oligomycin is a macrolide that acts as a specific inhibitor of the mitochondrial ATP-synthase and blocks oxidative phosphorylation. The compound is a mixture of isomers A ,B , and C .Cancer cell studies show that Oligomycin does not activate the hypoxia-induced factor, however, it enhances the bioenergetic adaptation of heterogeneous bioenergetically organized cells. Oligomycin has been shown to decreased the cyclin D1 protein expression levels
A specific inhibitor of the mitochondrial ATP-synthase.
相关属性
| CAS编号 | 1404-19-9 |
|---|---|
| 敏感性 | 对湿度敏感;对光敏感 |
| 熔点 | 84-100°C |
| 溶解性 | Soluble in EtOH, acetone (50 mg/ml), DMSO (300 mg/ml), ethanol, and methanol. Insoluble in water |
| 储存温度 | 避光,-20°C储存,充氩 |
| MDL号 | MFCD00065705 |
| 分子量 | 791.07(for Oligomycin A) |
| 分子式 | C45H74O11 |
| EC号 | MFCD01779388 |
| 品牌 | Jinpan |
| 备注 | 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| PubChem CID | 24898006 |