伊曲康唑
基本信息
| 产品名称 | 伊曲康唑 |
|---|---|
| 英文名称 | Itraconazole |
| 别名 | 伊曲康唑；4-[4-[4-[4-[[2-(2,4-二氯苯基)-2-(1H-1,2,4-三唑-1-基甲基)-1,3-二氧戊环-4-基]甲氧基]苯基]-1-哌嗪基]苯基]-2,4-二氢-2-(1-甲基丙基)-3H-1,2,4-三唑-3-酮；斯皮仁诺；依他康唑；亚特那唑；奥立康唑；孢粉； R51211 |
| 英文别名 | Oriconazole;R51211;Sporanox;2-butan-2-yl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one |
| 应用 | A traizole antifungal agent |
| 规格或纯度 | ≥98%(HPLC) |
| 运输条件 | 冰袋运输 |
| 生化机理 | 细胞色素p450 CYP3A4抑制剂（咪达唑仑羟基化的IC 50 = 16-26 nM）。对真菌酶的亲和力高于哺乳动物细胞色素p450。穿越血脑屏障的能力有限。抗真菌活性。 |
一般描述
Itraconazole is a triazole antifungal agent. It inhibits the fungal CYP(cytochrome P450) oxidase-mediated synthesis of ergosterol. Itraconazole also acts as an effective hedgehog signaling inhibitor in a Ptch-independent manner, presumably by binding smoothened (Smo) at a site distinct from that targeted by cyclopamine and SAG. Itraconazole is an inhibitor of CYP3A4.A traizole antifungal agent
Itraconazole is a triazole antifungal agent. It inhibits the fungal CYP(cytochrome P450) oxidase-mediated synthesis of ergosterol. Itraconazole also acts as an effective hedgehog signaling inhibitor in a Ptch-independent manner, presumably by binding smoothened (Smo) at a site distinct from that targeted by cyclopamine and SAG. Itraconazole is an inhibitor of CYP3A4.
A traizole antifungal agent
相关属性
| CAS编号 | 84625-61-6 |
|---|---|
| 敏感性 | 对热敏感 |
| 熔点 | 167.0 to 171.0 °C |
| 溶解性 | Soluble in chloroform (50 mg/ml), DMF (~0.5 mg/ml), DMSO (50 mM), water (<1 mg> |
| 储存温度 | 2-8°C储存 |
| Reaxys-RN | 6042047 |
| RTECS | XZ5481000 |
| MDL号 | MFCD00870168 |
| 分子量 | 705.63 |
| 分子式 | C35H38Cl2N8O4 |
| 品牌 | Jinpan |
| 备注 | 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| PubChem CID | 3793 |