丙甲菌素
基本信息
| 产品名称 | 丙甲菌素 |
|---|---|
| 英文名称 | Alamethicin |
| 别名 | 丙甲甘肽；阿拉霉素 |
| 英文别名 | Antibiotic U-22324;N-Acetyl-2-methylalanyl-L-prolyl-2-methylalanyl-L-alanyl-2-methylalanyl-L-alanyl-L-glutaminyl-2-methylalanyl-L-valyl-2-methylalanylglycyl-L-leucyl-2-methylalanyl-L-prolyl-L-valyl-2-methylalanyl-2-methylalanyl-L-α-glutamyl-N1-[(2R)-1-hyd |
| 规格或纯度 | ≥98.0% |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | Monovalent cation ionophore; can mimic nerve action potential across artificial membranes.Peptide antibiotic from the fungus Trichoderma viride. Forms voltage-dependent ion channels in the lipid bilayer of cell membranes. Inhibits non-specific ion efflux through the membrane. |
一般描述
Alamethicin (U-22324) is a polypeptide natural product antibiotic supplied as a mixture of homologs: Alamethicin and Alamethicin I. These compounds form voltage-dependent ion channels in the lipid bilayer, throμgh the spontaneous assembly of units into a multimeric barrel-stave structure spanning the membrane. This formation results in a hydrophilic pore which permits non-specific ion efflux throμgh the membrane. The non-specific ion efflux obliterates the normal electrochemical gradient of the cell, producing the antibiotic property of Alamethicin. Substantiated by experiments with covalently tethered molecules of Alamethicin, It is sμggested that different multimeric aggregation states create varying pore sizes with varying stabilities, correlating to differential specificity for ions. This channel-forming activity has been exploited as a tool for introducing hydrophilic small molecules into mitochondria without disrupting the integrity of the membrane.Alamethicin is a monovalent cation ionophore which can mimic nerve action potential across artificial membranes. Alamethicin has also been used for studying membrane interactions of antimicrobial peptides.
Alamethicin (U-22324) is a polypeptide natural product antibiotic supplied as a mixture of homologs: Alamethicin and Alamethicin I. These compounds form voltage-dependent ion channels in the lipid bilayer, through the spontaneous assembly of units into a multimeric barrel-stave structure spanning the membrane. This formation results in a hydrophilic pore which permits non-specific ion efflux through the membrane. The non-specific ion efflux obliterates the normal electrochemical gradient of the cell, producing the antibiotic property of Alamethicin. Substantiated by experiments with covalently tethered molecules of Alamethicin, It is suggested that different multimeric aggregation states create varying pore sizes with varying stabilities, correlating to differential specificity for ions. This channel-forming activity has been exploited as a tool for introducing hydrophilic small molecules into mitochondria without disrupting the integrity of the membrane.
Alamethicin is a monovalent cation ionophore which can mimic nerve action potential across artificial membranes. Alamethicin has also been used for studying membrane interactions of antimicrobial peptides.
相关属性
| CAS编号 | 27061-78-5 |
|---|---|
| 敏感性 | 对光线和湿度敏感 |
| 熔点 | 252°C-272°C |
| 溶解性 | Soluble in DMSO and ethanol，Methanol |
| 储存温度 | -20°C储存 |
| MDL号 | MFCD00151517 |
| 分子量 | 1964.34 |
| 分子式 | C92H150N22O25 |
| 品牌 | Jinpan |
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| PubChem CID | 53229968 |